This lecture introduces the pharmacological agents used to treat mycobacterial infections, primarily tuberculosis (TB) caused by Mycobacterium tuberculosis, and less commonly non-tuberculous mycobacteria and leprosy (Hansen’s disease).

This lecture focuses on quinolones and fluoroquinolones, a class of bactericidal antibiotics that act by inhibiting bacterial DNA replication. It explains how these drugs target DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for bacterial DNA supercoiling and separation.

This lecture provides an in-depth look at macrolide antibiotics, a widely used class of bacteriostatic agents that inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit. The lecture explores their mechanism of action, spectrum of activity, common therapeutic indications, and resistance mechanisms.

This lecture explores antibiotics that inhibit bacterial protein synthesis, focusing on how they target the bacterial ribosome  without affecting human ribosomes . These agents are essential in treating a wide range of bacterial infections, particularly when β-lactams are not suitable.

Students will learn the site of action, mechanism, classification, and clinical uses of key drug classes, along with common resistance mechanisms and adverse effects.