Lecturer
Its study the effects of the body on the administered drug (movement of drug inside
the body).
It represent four steps Absorption, Distribution, Metabolism and Excretion.
[ADME]
Absorption: The transport of drug from the administration site to the blood
stream crossing different biological membranes.
Distribution: The transfer of drug from bloodstream into the interstitial space of
tissue and then into cell .
Metabolism: The enzymatic alteration in the structure of drug to more hydrophilic
products to be easily excreted.
• Excretion: The movement of drugs and their metabolites outside the body by
different routes of excretion.
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