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Trypanosomes are hemoflagellates that reside in peripheral blood and tissues of their host.
- Trypanosoma cruzi : It is the causative agent of South American trypanosomiasis (also called as Chagas’ disease) in man and transmitted by insect vector reduviid bug
- Trypanosoma brucei: It causes African trypanosomiasis, transmitted by tsetse fly. It has three important subspecies out of which only two of them infect humans
- Trypanosma brucei rhodesiense: is the causative agent of East African sleeping sickness
- Trypanosma brucei gambiense: It is the causative agent of West African sleeping sickness
- Trypanosoma rangeli: It is a nonpathogenic species .

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