Lecturer
Megaloblastic Anemia (macrocytic)
It is a form of anemia characterized by very large red blood cells and a decrease in the number of those cells. It was result from inhibition of DNA synthesis during red blood cell production. When DNA synthesis is impaired, the cell cycle cannot progress from the G2 growth stage to the mitosis (M) stage. This leads to continuing cell growth without division, which presents as macrocytosis. The defect in red cell DNA synthesis is most often due to vitamin B12 deficiency or folate deficiency.
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